Devil's claw (Harpagophytum procumbens) has been shown to have an anti-inflammatory effect in humans and laboratory animals.
The active ingredients are various iridoid glycosides, acetylated phenolic glycosides, and terpenoids.
The major chemical constituents of Harpagophytum are iridoid glycosides, phytosterols, aromatic acids, and flavonoids. Glycosides found in the tubers of the plant appear to be the most therapeutically important constituents.
Taking devil's claw by mouth has been shown to reduce low-back pain. Devil's claw seems to work about as well as some non-steroidal anti-inflammatory drugs (NSAIDs) on pain associated with Osteoarthritis. Taking devil's claw alone, with other ingredients, or along with nonsteroidal anti-inflammatory drugs (NSAIDs) seems to help decrease osteoarthritis-related pain human studies have shown.
Devils claw: Can reduce pain in the joints caused by inflammatory conditions like osteoarthritis (it contains a range of Glycosides which appear to be the most therapeutically important constituent, like harpagoside alongside many others).
Laboratory studies found that extracts from the plant can block several pathways which cause joint inflammation. Harpagoside is said to be responsible for this.
Harpagoside: Harpagoside is characterized as an iridoid glycoside. It Is the active ingredient in Devils claw that give it its anti-inflammatory properties.
Glycosides: Glycosides are a wide variety of naturally occurring substances in which a carbohydrate portion, consisting of one or more sugars or a uronic acid. is combined with a hydroxy compound. The hydroxy compound, usually a non-sugar entity also called a aglycon.
uronic acid: Uronic acid is a carbohydrate containing both a carboxylic acid and an aldehyde or ketone.
Carboxylic acid: Carboxylic acid is a number of organic compounds in which a carbon (C) atom is bonded to an oxygen (O) atom by a double bond and to a hydroxyl group (―OH) by a single bond. A fourth bond links the carbon atom to a hydrogen (H) atom or to some other univalent group.
Univalent: Having a valence of one aka monovalent. Valence refers to the amount of bonds it has, so this means space for 1 bond.
Hydroxy: A hydroxy or hydroxyl group is a functional molecular group with formula -OH.
Its composed of 1 oxygen atom covalently bonded to 1 hydrogen atom.
Aglycon: a noncarbohydrate group, usually an alcohol or phenol, combined with a sugar to form a glycoside.
Phenol: Phenol is an organic hydroxy compound that consists of benzene bearing a single hydroxy substituent. The parent of the class of phenols.
Benzene: Benzene is an organic chemical compound with the molecular formula C6H6. The benzene molecule is composed of six carbon atoms joined with one hydrogen atom attached to each. Because it contains only carbon and hydrogen atoms, benzene is classed as a hydrocarbon.
Note: Always refer to a professional herbalist or doctor before using herbs medicinally, we make no claims as to the medicinal use of our herbal products. There are many clinical trials and research that can help you to understand the uses of herbs.
Always check with a licensed herbalist or practitioner/doctor when using herbal supplements for specific issues or if on medication or pregnant.
This is for information purposes only.